Steroid-resistant inflammation in a mouse model of severe asthma is inhibited by the combination of Theophylline and Dexamethasone
Severe asthma patients present with a steroid-resistant neutrophilic airway inflammation which is poorly controlled by steroids, even when additional high dose oral steroid treatment is used. This feature of the disease shows some similarity to the steroid-resistant neutrophilic inflammation associated with chronic obstructive pulmonary disease (COPD). It has previously been shown in mouse models of COPD that the use of Theophylline in combination with steroid restores steroid sensitivity to this inflammatory response. Here we investigated the combination of Theophylline and steroid in a mouse model of severe asthma to determine the effects on neutrophilic inflammation and show whether there is a mechanistic similarity with the mouse COPD model.