Phosphazenes as organosuperbases for Darzens reaction

Darzens reactions are commonly run in the presence of strong anionic bases such as alkali metal hydroxides or alkoxides, sodium amide, LDA, LiHMDS or n-butyllithium, very often with pre-formation of the reactive ester enolate anion. To the best of our knowledge, there are not examples of Darzens reaction involving uncharged organobase. Prompted by this information, we surveyed the activity of readily available organobases with different pKBH+3 in the Darzens condensation between α-halo esters and aromatic aldehydes.

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Aptuit | Phosphazenes as organosuperbases for Darzens reaction

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