Extensive resources. Expert teams
Our team of experts in translational biomedicines, in vitro pharmacology and electrophysiology collaborates closely with colleagues from other departments, such as Medicinal Chemistry and DMPK. We apply our expertise to generate knowledge, and our in vitro and translational models and technologies can be used flexibly for fully-integrated projects, small multi-staged pieces of work or standalone studies.
In vitro Pharmacologists develop and perform biochemical, cellular, biophysical assays over a wide range of biological target classes, such as GPCRs, kinases, ion channels, protein-protein interactions. Appropriate screening technologies are applied to generate high-quality data in short turnaround times. The team is particularly capable in classical pharmacological analysis to provide “mode of action” studies – a key parameter in the pharmacology of compounds and important determinant for probability of successful translation to the clinic.
Our in vitro electrophysiology capabilities include conventional or automated (Rapid ICE) Ion Channel Electrophysiology from the single cell to isolated tissue.
The Translational Pharmacology Department helps you to progress your projects from in vitro studies to the selection of high-quality candidate by:
- Producing robust mechanistic PK/PD relationships to determine target engagement, the active concentration in biophase, plasma exposure for efficacy and potential therapeutic window
- Using truly translational approaches to shape the design of early human studies (Central and peripheral biomarkers, receptor occupancy, pEEG)
- Establishing a correlation between in vitro potency, drug efficiency and in vivo efficacy
- Determining the efficacy in animal models relevant to the disease of interest
- Discriminating the target profile with respect to current drugs in the market and providing data to support differentiation strategies