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Aptuit | In vitro dissolution screening for PK formulation | AAPS 2016

In vitro dissolution screening for PK formulation selection for poorly water-soluble drugs: a case study

Accurate prediction of in vivo biopharmaceutical performance of oral formulations is an important step for drug development, especially for BCS class II compound as the present candidate.

Different formulation strategies have been proposed and applied for a poorly water-soluble drug (Compound A). The objective of this study was to screen in vitro dissolution rate of different formulation prototypes described in previous work.

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