Resources

Development Stage

Resource Type

Aptuit | Practical usage of the drug efficiency concept to boost the quality of clinical candidates in CNS drug discovery

Practical usage of the Drug Efficiency concept in CNS drug discovery

Presented by Alfonso Pozzan at the CHI 2017 Drug Discovery Chemistry conference, this scientific poster discusses the concept of Drug Efficiency (Deff) in Lead Optimization, the use of Deff in CNS marketed drugs and addresses the future of Deff. Get your copy now!

Aptuit | Prediction of Drug Efficiency: Aptuit's experience in CNS drug design and discovery

Prediction of Drug Efficiency

Presented by Alfonso Pozzan at CHI Drug Discovery Chemistry 2017, this presentation discusses the concept of CNS Drug Efficiency, the methods used to model DrugEff and analysis to summarise what the best option is.

Aptuit | Design, synthesis and in vitro profiling of novel inhibitors of P. aeruginosa Multi-virulence factor Regulator (MvfR)

Design, synthesis and in vitro profiling of novel inhibitors

Recently presented by our Director, Medicinal Chemistry, Daniele Andreotti, at ECCMID 2017, get your copy of this educational scientific poster today to review the research program that was initiated to discover novel, potent inhibitors and examine the results and data of prototype compound M64.

Aptuit | Paul Overton

The shifting sands of early stage R&D

Paul Overton, Aptuit’s Executive Vice President of business development and marketing, a scientist by background, talks to Jo Shorthouse about the evolving R&D
model and how the CRO industry can work creatively on early stage research.

Aptuit | Why we need a culture of international collaboration to fight antibiotic resistance

Antibiotic resistance

Antimicrobial resistance poses one of the biggest threats to public health faced in modern times. Left unchecked, it’s thought that by 2050 the global number of deaths from antimicrobial resistance may be as high as 10 million per year. In addition to the human cost, the financial burden will be substantial. Download this scientific article today and discover more.

Aptuit | Respiratory Fibrosis

Respiratory Fibrosis: future focus for developing novel treatments

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive pathology which leads to a gradual loss of pulmonary function. The pathology is characterised by accumulation of fibrotic tissue due to abnormal ECM remodelling. Currently, the market only offers therapies targeting the symptoms, rather than the causes, which are largely unknown. This article covers current treatment options, targets and current pipeline and looks ahead to the development of novel compounds.

Aptuit | The dynamics of the growing respiratory drug market

The dynamics of the growing respiratory drug market

Our report, "A rising future: The dynamics of the growing respiratory drug market" discusses the currently available treatments for respiratory diseases, our main challenges, and finally what lies ahead.

Aptuit | A guide to optimizing your API strategy

A guide to optimizing your Active Pharmaceutical Ingredient strategy

Central to drug development is the Active Pharmaceutical Ingredient (API), the synthesis of which is no easy feat. Download this API eBook and ensure you know how to successfully pass each milestones.

Aptuit | Drug discovery in the 21st century

Drug Discovery in the 21st Century

Our latest ebook has been created to help unravel the drug discovery process and provide guidance on how to save time, money and resources while increasing your chances of success. Read it for an overview of the dynamic stages of the drug discovery process and key factors to consider to increase your chances of success.

Aptuit | Development and validation of a bioanalytical method - EBF 2016

Development and validation of a bioanalytical method for quantification of LNA-i-miR-221

Presented at EBF 2016, this scientific poster showcases the development and validation of a bioanalyticaly method for quantification of LNA-i-miR-221, a 13-mer oligonucleotide, in rat plasma using LC-MS/MS.

Aptuit | Compliance and work efficiency improvements through implementation of a UNIFI Network - EBF 2016

Compliance and work efficiency improvements through implementation of a UNIFI Network

Recently presented at EBF 2016, download your copy of the educational 'Compliance and work efficiency improvements through implementation of a UNIFI Network' presentation and discover more about the key aspects of regulated Bioanalysis.

Aptuit | Benefits of high sensitivity clinical case studies and overall lab productivity - EBF 2016

Benefits of high sensitivity clinical case studies and overall lab productivity

Recently presented at EBF 2016, download your copy of the educational presentation, 'Benefits of high sensitivity clinical case studies and overall lab productivity' and explore two case studies in detail.

Aptuit | Validation of MITRA sampling technology for drug discovery PK studies

Validation of MITRA sampling technology for drug discovery PK studies

Recently presented at SLAS 2017, download your copy of this scientific poster and understand more about MITRA sampling technology for drug discovery PK studies.

Aptuit | Preclinical Formulation: Design, development and bioavailability considerations webinar

Preclinical Formulation: Design, development and bioavailability considerations

Listen to this informative webinar and find out how to overcome the challenges of preclinical formulation development.

Aptuit | Challenging high drug tolerance observed during the validation of a direct solid-phase ADA ELISA - EBF 2016

Validation of a direct solid-phase ADA ELISA for the screening and confirmation of anti-human Protein X antibodies in mouse serum samples

Recently presented by our experts at EBF 2016, discover more about Protein X antibodies in mouse serum samples with this scientific poster.

Aptuit | in vitro dissolution for PK formulation - AAPS 2016

In vitro dissolution screening for PK formulation

Presented at AAPS 2016, discover more with this case study about in vitro dissolution screening for PK formulation selection for poorly water-soluble drugs.

Aptuit | Quality by Design

How Quality by Design translates into practice

In this webinar we discuss how Quality by Design principles, introduced in the ICH Q8, Q9, Q10 and Q11, were used to support development studies for Drug Substance and Drug Product.

Aptuit | Integrated approach to data management

An integrated approach to data management from assay request to data storage

Discover the advantages of applying a workflow driven approach to assay request and data collection in drug discovery and development organisations.

Aptuit | enabling technology and formluation selection - AAPS 2016

Enabling technology screening and formulation selection for poorly water-soluble drugs

Presented at AAPS 2016, download this scientific poster to find out more about enabling technology screening and formulation selection in poorly water-soluble drugs.

Particle Engineering From API Solid Form to Formulation

Particle Engineering: From API Solid Form to Formulation

This webinar provides insights about approaches to characterize and modify the API particle attributes to fit formulation need.

Aptuit | Profiling a compound library

Profiling of a compound library biased toward immunomodulating agents

Recent successes of immunomodulatory approaches for the treatment of serious diseases such as cancer have generated a significant growth in efforts aimed at the discovery...

Aptuit | Antibacterial Discovery

Driving Innovation Back Into Antibacterial Discovery

In this webinar Antonio Felici discusses antibacterial resistance and the need for new and right antibiotics, providing examples of innovative discovery approaches.

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How to be successful in API outsourcing

Stephen Gorsuch presents our webinar discussing how to ensure your active pharmaceutical ingredient outsourcing activities are as successful as possible

Aptuit | Accelerated stability assessment program

Accelerated stability assessment program to improve product development

Watch our webinar discussing accelerated stability assessment programs (ASAP)  to improve product development.

Aptuit | Bioenhancement of poorly water soluble drugs

Bioenhancement of poorly water soluble drugs

In this webinar we address the influence of drug solid state properties on solubility and applications to pharmaceutical products development.

Aptuit | Pharmaceutical drug abuse liability assessment

Pharmaceutical drug abuse liability assessment

Watch our webinar on Pharmaceutical abuse liability assessments. In this we address the definitions of Abuse Liability, scheduling process, implications and guidelines, general principles and considerations, methods (tiered approach) and preclinical studies (methods and examples).