Resources

Development Stage

Resource Type

Aptuit | Cytology and Histology of the CNS: Part One

Cytology and Histology of the CNS: Part One

This webinar briefly describes the cellular populations of the central nervous system, their functions and interrelationships and is aimed at an audience of training pathologists both in the veterinary or toxicology fields.

Aptuit | Cytopathology, Artifacts and 'non-lesions' of the CNS: Part Two

Cytopathology, Artifacts and 'non-lesions' of the CNS: Part Two

This webinar offers a short overview on the CNS cytopathology; and additionally, the most common handling/fixation artifacts and neuroanatomic structures that can be confused with lesions. This webinar is aimed to an audience of training pathologists both in the veterinary or toxicology fields.

Aptuit | Data Integrity Principles

Data Integrity Principles

This webinar will -

  • Provide a basic training on the data integrity to all people involved in GMP activities
  • Review the meaning of data integrity, why it is important in a pharmaceutical company and the principles defined in the guidelines and how to apply them to a QC lab
  • Share examples of a computerized process for managing the laboratory activities, that ensures traceability and integrity of the data throughout the process

Aptuit | KF method development for Coulometric KF with oven

KF method development for Coulometric KF with oven

Automated coulometric KF with oven, when feasible, allows the analysis of a large sample number and requires a small amount of sample. This webinar discusess how to approach a method development using this technique.

Aptuit | Smart Lead Optimization: Novel approaches to the selection of higher quality clinical candidates

Smart Lead Optimization: Novel approaches to the selection of higher quality clinical candidates

Recently presented at IDDST 2017 by our expert, Luca Raveglia, this presentation focuses on attrition rate in Drug Discovery and Development and Lead Optimization strategies.

Aptuit | Capsule based Dry Powder Inhaler (DPI) for Phase I

Capsule based Dry Powder Inhaler (DPI) for Phase I

In this webinar, Wayne examines capsule based Dry Powder Inhaler (DPI) for Phase I, and in particular, addresses the following areas -

  • Advantages of pulmonary delivery
  • Main types of DPI devices
  • Basic principles of DPI's
  • In vitro testing using Next Generation Impactor
  • What the future holds

Aptuit | SFC technology vs HPLC in chiral separations and the role of chiroptical detection: part two

SFC technology vs HPLC in chiral separations and the role of chiroptical detection: part two

Part two of this two part webinar mini-series presents some real examples about the use of SFC technology in chiral separations and the role of Circular Dichroism (CD) detection, in particular:

  • The utility of CD in chiral analyses
  • The automation in semipreparative SFC chiral separations
  • SFC versus HPLC: examples and costs analysis

Aptuit | SFC technology vs HPLC in chiral separations and the role of chiroptical detection: part one

SFC technology vs HPLC in chiral separation and the role of chiroptical detection: part one

Part one of this two part webinar mini-series presents aspects about SFC technology, in particular:

  • What is SFC technique and why are SFC and HPLC considered complementary techniques in chiral analyses?
  • Analytical and semipreparative SFC aspects
  • What is Circular Dichroism (CD) and why is it often useful in chiral analyses?

Aptuit | Bioavailability enhancement in drug product development

Bioavailability enhancement in drug product development

This webinar discusses approaches for the bio-availability enhancement of oral dosage from drug products. Including: solid dispersions, nano-suspensions and lipidic formulations and targeted delivery.

Aptuit | Computational chemistry approach for in silico screening of novel inhibitors of P. aeruginosa MvfR

Computational chemistry approach for in silico screening of novel inhibitors of P. aeruginosa MvfR

Recently presented by our expert, Vanesa Garrido Estevez, a structure-based in silico screening approach was performed following docking studies on
M64, a compound showed to inhibit the MvfR regulon, in order to search for novel inhibitors of MvfR protein.

Aptuit | QbD in the early clinical phase development: why is this useful?

QbD in the early clinical phase development: why is this useful?

Quality by Design (QbD) aims to deliver the safe, effective drug supply to the patients/ consumers, and also offers significant improvement to manufacturing quality performance. This webinar examines and analyses why QbD in the early clinical phase development is useful.

Aptuit | Bola-shaped Glycocalix[4]arenes for efficient and specific drug delivery systems

Bola-shaped Glycocalix[4]arenes for efficient and specific drug delivery systems

Recently presented at RICT 2017 by our expert, Marta Giuliani, download your copy of this scientific poster now and discover more about Glycocalix[4]arenes' combination with traditional liposomes to produce new potential systems for efficient and specific targeted drug delivery, based on carbohydrate-protein recognition.

Aptuit | Prediction of Drug Eff: Aptuit's experience in CNS drug design and discovery

Prediction of Drug Eff: Aptuit's experience in CNS drug design and discovery

It is widely accepted that CNS drugs need to have some distinctive physchem properties to penetrate the blood-brain barrier and exhibit CNS activity. This webinar addresses the concept of CNS Drug Efficiency, methods used to model DrugEff and the summarises the analysis found and what is the best option.

Aptuit | Four challenges for pulmonary drug delivery

Four challenges for pulmonary drug delivery

This article reviews the issues specific to developing drugs designed for pulmonary delivery and considers how - with the right knowledge and expertise - these challenges can be overcome.

Aptuit | Systems Biology in drug discovery: target identification and biomarkers discovery

Systems biology in drug discovery

This webinar introduces you to systems biology approaches in drug discovery; providing an overview on biological networks and network analysis and examples on application of systems biology approaches in Drug Discovery in two areas of research: target identification (Alzheimer's) and Biomarkers discovery.

Aptuit | TRAC: An alternative method to measure CYP induction

TRAC: An alternative method to measure CYP induction

Recently presented by our expert Francesco Rossignolo at the 14th European meeting of the International Society for the Study of Xenobiotics (ISSX) in Germany, download your copy of this scientific poster today and discover more about CYP induction.

Aptuit | Application of HCA in Drug Discovery and Mode of Action studies

Application of HCA in Drug Discovery and Mode of Action studies

Recently presented by our expert, Rosaria Remelli, at the Drug Discovery Summit in Berlin, discover more about HCA application with this educational presentation.

Aptuit | Genetic Toxicology: how the test system impacts the in vitro testing quality | Webinar

Genetic Toxicology: how the test system impacts the in vitro testing quality

The aim of this webinar is to highlight the critical aspects related to the test system in the genetic toxicology testing, and to provide insights on its characterization, to ensure the required quality standards.

Aptuit | Genetic toxicology: beyond standard test | Webinar

Genetic toxicology: beyond standard test

This webinar looks at some of the different types of genetic toxicity testing, including the Ames test: modified pre-incubation test, Chromosome Abberation test: longer harvesting test time and the Micronucleus test: CREST/FISH kinetochore test.

Aptuit | Design, synthesis and biological evaluation of a new series of 8-substituted purines for photoprotection and prevention of ultra violet (UV) related damages

Design, synthesis and biological evaluation of a new series of 8-substituted purines for photoprotection and prevention of UV related damages

There is an increasing interest in developing novel molecules especially if endowed with UV filtering and antioxidant activity. This scientific poster focuses on the synthesis of polyphenols and the evaluation of antioxidants as the first line of defense against skin cancer and early photo-ageing.

Aptuit | Preclinical development: the hard road to clinical

Preclinical development: the hard road to clinical

Presented by our expert, Mark Saunders, this presentation discusses the challenges in designing dose vehicles for preclinical studies, gastro-intestinal physiology considerations of common animal models and examines case stdies including pH variability, GI volume, metabolism and digestion.

Aptuit | How an early, integrated approach to formulation can simplify and accelerate drug development

How an early, integrated approach to formulation can simplify and accelerate drug development

Here, we draw on the experience of Mark Saunders, to find out more about how taking an integrated approach to drug formulation as early as possible in drug development can produce the best possible products with the greatest chance of success.

Aptuit | Rational design, synthesis and in vitro characterization of novel potent inhibitors

Rational design, synthesis and in vitro characterization of novel potent inhibitors

A discovery program was initiated to discover novel, potent inhibitors of MvfR regulon, starting from a chemical series firstly reported by L Rahme. Here we describe the design and the in vitro characterization of a novel chemical series of MvfR inhibitors designed from M64 taken as the prototype molecule.

Aptuit | In vitro ADMET profiling using High-Throughput RapidFire Mass Spectrometry

In vitro ADMET profiling using High-Throughput RapidFire Mass Spectrometry

This webinar, from our expert Raffaella Ricci, discusses the features and the potential applications of RapidFire system in DMPK assays along with HighThroughPut screenings.

Aptuit | Drug Discovery: HIT identification through HTS

Drug Discovery: HIT identification through HTS

In this webinar, Stephan Fasler addresses Hit identification through High-throughput screening. The main areas of discussion are around Hit discovery, lead-like compound collection and screening cascade. Listen now!

Aptuit | No PAINS, no gains: why over-reliance on computational PAINS filters could be a mistake

No PAINS, no gains: why over-reliance on computational PAINS filters could be a mistake

Using computational filters to exclude so-called Pan-Assay Interference Compounds, or PAINS, from high throughput screening campaigns has become increasingly common in drug discovery circles. But while the industry is right to be vigilant about ‘frequent hitters’(compounds that show misleading readouts in multiple biological assays) new findings add to growing concern that we blindly follow PAINS filters at our peril.

Aptuit | How QbD theory translates into practice | Part 1 webinar

How QbD theory translates into practice: part 1

Part one of this three-part mini-series introduces Quality by Design (QbD) concepts applied to Active Pharmaceutical Ingredient and Drug Product. This webinar is aimed at an audience that does not have much experience with QbD.

Aptuit | How QbD theory translates into practice: part 2

How QbD theory translates into practice: part 2

Part two of this three-part mini-series presents case studies on the application of QbD concepts. This webinar is aimed at both new, and more experienced, people who are interested in the practical application.

Aptuit | How QbD theory translates into practice: part 3

How QbD theory translates into practice: part 3

This final webinar of the series discusses QbD at the pre-formulation stage and the approach to process development. With a focus on Drug Product case studies, QbD at Pre-formulation stage and approaches to Process Development.

Aptuit | BMPR1A receptor role during mouse Embryonic Stem Cells (mESCs) in vitro differentiation

BMPR1A receptor role during mouse Embryonic Stem Cells (mESCs) in vitro differentiation

One of the main goals in stem cells biology is the identification of factors regulating self-renewal and differentiation. In this poster, the role of BMPR1A receptor in mouse Embryonic Stem Cells (mESCs) was investigated in in vitro differentiation.

Aptuit | Practical usage of the drug efficiency concept to boost the quality of clinical candidates in CNS drug discovery

Practical usage of the Drug Efficiency concept in CNS drug discovery

Presented by Alfonso Pozzan at the CHI 2017 Drug Discovery Chemistry conference, this scientific poster discusses the concept of Drug Efficiency (Deff) in Lead Optimization, the use of Deff in CNS marketed drugs and addresses the future of Deff. Get your copy now!

Aptuit | Prediction of Drug Efficiency: Aptuit's experience in CNS drug design and discovery

Prediction of Drug Efficiency

Presented by Alfonso Pozzan at CHI Drug Discovery Chemistry 2017, this presentation discusses the concept of CNS Drug Efficiency, the methods used to model DrugEff and analysis to summarise what the best option is.

Aptuit | Design, synthesis and in vitro profiling of novel inhibitors of P. aeruginosa Multi-virulence factor Regulator (MvfR)

Design, synthesis and in vitro profiling of novel inhibitors

Recently presented by our Director, Medicinal Chemistry, Daniele Andreotti, at ECCMID 2017, get your copy of this educational scientific poster today to review the research program that was initiated to discover novel, potent inhibitors and examine the results and data of prototype compound M64.

Aptuit | Paul Overton

The shifting sands of early stage R&D

Paul Overton, Aptuit’s Executive Vice President of business development and marketing, a scientist by background, talks to Jo Shorthouse about the evolving R&D
model and how the CRO industry can work creatively on early stage research.

Aptuit | Why we need a culture of international collaboration to fight antibiotic resistance

Antibiotic resistance

Antimicrobial resistance poses one of the biggest threats to public health faced in modern times. Left unchecked, it’s thought that by 2050 the global number of deaths from antimicrobial resistance may be as high as 10 million per year. In addition to the human cost, the financial burden will be substantial. Download this scientific article today and discover more.

Aptuit | Respiratory Fibrosis

Respiratory Fibrosis: future focus for developing novel treatments

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive pathology which leads to a gradual loss of pulmonary function. The pathology is characterised by accumulation of fibrotic tissue due to abnormal ECM remodelling. Currently, the market only offers therapies targeting the symptoms, rather than the causes, which are largely unknown. This article covers current treatment options, targets and current pipeline and looks ahead to the development of novel compounds.

Aptuit | The dynamics of the growing respiratory drug market

The dynamics of the growing respiratory drug market

Our report, "A rising future: The dynamics of the growing respiratory drug market" discusses the currently available treatments for respiratory diseases, our main challenges, and finally what lies ahead.

Aptuit | A guide to optimizing your API strategy

A guide to optimizing your Active Pharmaceutical Ingredient strategy

Central to drug development is the Active Pharmaceutical Ingredient (API), the synthesis of which is no easy feat. Download this API eBook and ensure you know how to successfully pass each milestones.

Aptuit | Drug discovery in the 21st century

Drug Discovery in the 21st Century

Our latest ebook has been created to help unravel the drug discovery process and provide guidance on how to save time, money and resources while increasing your chances of success. Read it for an overview of the dynamic stages of the drug discovery process and key factors to consider to increase your chances of success.

Aptuit | Development and validation of a bioanalytical method - EBF 2016

Development and validation of a bioanalytical method for quantification of LNA-i-miR-221

Presented at EBF 2016, this scientific poster showcases the development and validation of a bioanalyticaly method for quantification of LNA-i-miR-221, a 13-mer oligonucleotide, in rat plasma using LC-MS/MS.

Aptuit | Compliance and work efficiency improvements through implementation of a UNIFI Network - EBF 2016

Compliance and work efficiency improvements through implementation of a UNIFI Network

Recently presented at EBF 2016, download your copy of the educational 'Compliance and work efficiency improvements through implementation of a UNIFI Network' presentation and discover more about the key aspects of regulated Bioanalysis.

Aptuit | Benefits of high sensitivity clinical case studies and overall lab productivity - EBF 2016

Benefits of high sensitivity clinical case studies and overall lab productivity

Recently presented at EBF 2016, download your copy of the educational presentation, 'Benefits of high sensitivity clinical case studies and overall lab productivity' and explore two case studies in detail.

Aptuit | Validation of MITRA sampling technology for drug discovery PK studies

Validation of MITRA sampling technology for drug discovery PK studies

Recently presented at SLAS 2017, download your copy of this scientific poster and understand more about MITRA sampling technology for drug discovery PK studies.

Aptuit | Preclinical Formulation: Design, development and bioavailability considerations webinar

Preclinical Formulation: Design, development and bioavailability considerations

Listen to this informative webinar and find out how to overcome the challenges of preclinical formulation development.

Aptuit | Challenging high drug tolerance observed during the validation of a direct solid-phase ADA ELISA - EBF 2016

Validation of a direct solid-phase ADA ELISA for the screening and confirmation of anti-human Protein X antibodies in mouse serum samples

Recently presented by our experts at EBF 2016, discover more about Protein X antibodies in mouse serum samples with this scientific poster.

Aptuit | in vitro dissolution for PK formulation - AAPS 2016

In vitro dissolution screening for PK formulation

Presented at AAPS 2016, discover more with this case study about in vitro dissolution screening for PK formulation selection for poorly water-soluble drugs.

Aptuit | Quality by Design

How Quality by Design translates into practice

In this webinar we discuss how Quality by Design principles, introduced in the ICH Q8, Q9, Q10 and Q11, were used to support development studies for Drug Substance and Drug Product.

Aptuit | Integrated approach to data management

An integrated approach to data management from assay request to data storage

Discover the advantages of applying a workflow driven approach to assay request and data collection in drug discovery and development organisations.

Aptuit | enabling technology and formluation selection - AAPS 2016

Enabling technology screening and formulation selection for poorly water-soluble drugs

Presented at AAPS 2016, download this scientific poster to find out more about enabling technology screening and formulation selection in poorly water-soluble drugs.

Particle Engineering From API Solid Form to Formulation

Particle Engineering: From API Solid Form to Formulation

This webinar provides insights about approaches to characterize and modify the API particle attributes to fit formulation need.

Aptuit | Profiling a compound library

Profiling of a compound library biased toward immunomodulating agents

Recent successes of immunomodulatory approaches for the treatment of serious diseases such as cancer have generated a significant growth in efforts aimed at the discovery...

Aptuit | Antibacterial Discovery

Driving Innovation Back Into Antibacterial Discovery

In this webinar Antonio Felici discusses antibacterial resistance and the need for new and right antibiotics, providing examples of innovative discovery approaches.

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How to be successful in API outsourcing

Stephen Gorsuch presents our webinar discussing how to ensure your active pharmaceutical ingredient outsourcing activities are as successful as possible

Aptuit | Accelerated stability assessment program

Accelerated stability assessment program to improve product development

Watch our webinar discussing accelerated stability assessment programs (ASAP)  to improve product development.

Aptuit | Bioenhancement of poorly water soluble drugs

Bioenhancement of poorly water soluble drugs

In this webinar we address the influence of drug solid state properties on solubility and applications to pharmaceutical products development.

Aptuit | Pharmaceutical drug abuse liability assessment

Pharmaceutical drug abuse liability assessment

Watch our webinar on Pharmaceutical abuse liability assessments. In this we address the definitions of Abuse Liability, scheduling process, implications and guidelines, general principles and considerations, methods (tiered approach) and preclinical studies (methods and examples).