Aptuit | In vitro electrophysiology

Electrophysiology

Extensive resources. Expert teams

Our extensive range of In Vitro Pharmacology services, from the single cell to isolated tissue, encompasses conventional or automated (Rapid ICE) Ion Channel Electrophysiology and organ preparations. A key area of our expertise centers on cardiac electrophysiology services, supported and enabled by extensive resource and expert staff.

Aptuit | In vitro electrophysiology

Our services include:

hERG Channel
Protocols include screening study designs - single high concentration or IC50 screening – and full studies monitored for GLP compliance.

Sodium Channel
Protocols include screening study designs - single high concentration or IC50 screening – as well as GLP compliance monitoring and formulation analysis.

KCNQ1/mink
Our screening and concentration-response assays (IC50) of compounds for interactions with the KCNQ1/minK channel identify potential risk of QT prolongation in humans, and can be used as a screen in development candidate selection.

Kv1.5
Our screening and concentration-response assays (IC50) of compounds inhibit Kv1.5, and can be used as a screen in development candidate selection.

Cav1.2
Our testing of compounds for interactions with Cav1.2 channel identify potential cardiac risk in humans and can be used as a screen in development candidate selection.

Rapid ICE
Revolutionising the use of electrophysiology in drug discovery and development, our technology is improving productivity at reduced cost and informing the cardiac safety profile of drug candidates at an earlier development stage.

 

Protocols include screening study designs for preliminary safety assessment, ECG/MAP/LVP, Coronary flow/pressure, MAP duration, QT & QRS duration, LVDP, MAP triangulation (instability), frequency-dependence & restitution, effective refractory period.