Design, synthesis and biological evaluation of a new series of 8-substituted purines for photoprotection and prevention of ultra violet (UV) related damages

The Sun Protection Factor (SPF) is defined as the Ultra Violet (UV) energy required for producing a minimal erythema dose (MED) on protected skin, divided by the UV energy required to produce a MED on unprotected skin. UV filters and antioxidants are the first line of defense against skin cancer and early photo-ageing; prevention is the most effective strategy.

For these reasons there is an increasing interest in developing novel molecules especially if endowed with UV filtering and antioxidant activity. Thus, we focused our work on the synthesis of polyphenols and the evaluation of their above stated activities.

The present study describes the synthesis of a series of 6,8-disubstituted purines bearing an OH-group at position 6 and phenol or polyphenol at position 8 in order to yield novel photoprotectors endowed with UV-filtering and antioxidant properties. In order to explore the possibility of a multi-target approach, we have taken into account that mycosis and tumors are commonly associated with inflammation. In addition to the UV filter and antioxidant tests we also studied the antifungal and antiproliferative activities.

Aptuit | Design, synthesis and biological evaluation of a new series of 8-substituted purines for photoprotection

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