Crystallization Isolation and Drying Process Development
Small changes in synthesis, purification, or crystallization conditions can lead to different polymorphs. Of these steps, crystallization is often most crucial in process control. In the solid state chemistry group we have extensive experience in optimizing the crystallization process to ensure consistent API production with the desired solid state form. Additionally, the solid state chemists work closely with our global API teams when transitioning the crystallization process from lab scale to the pilot plant and then on to commercial manufacture.
Crystallization is the critical step in solid form control, but often those responsible for the development of a crystallization process are not crystallization specialists. Typically, this task is undertaken by a development chemist whose primary focus and principle skill lies in the area of chemical synthesis rather than product isolation. We have wide-ranging experience in all areas of crystallization and can guide your compound through the important crystallization stages: generation of the first crystals, polymorph, salt or cocrystal form selection, and development of a robust crystallization process. We will provide you with a process that ensures the solid form you manufacture meets your specifications and gives you the bulk properties you need, while reducing variability and achieving consistency and control.