The analytical sector of the solid state chemistry group offers a wide range of analytical chemistry solutions and techniques. Whether you have one sample or one thousand, we can quickly and cost effectively analyze your materials as well as perform analytical method testing for polymorphs and other solid forms. We are leaders in X-ray powder diffraction (XRPD) methods including pairwise distribution functions (PDF), Rietveld analysis and other computational strategies. If you need significant solid state structural characterization, including chemical manufacturing control (CMC) support, we can help. For initial drug substance characterization we offer complete solutions and development options.
We offer a wide variety of analytical techniques as detailed here. From simple straightforward analysis to more elaborate experiments such as imaging of solid dosage forms, we are able to tackle any solid form issue you may have. All analytical work is carried out in strict compliance with cGMP requirements. Two types of reports are available for analytical standard priority submissions:
1. Non-Interpretative Report - Available for XRPD, IR, Raman, DSC and TG. A cGMP report will be issued within five days of sample receipt. The study will be billed at analysis price only.
2. Interpretative Report - A cGMP interpretative report will be issued within seven to 10 days. The study will be billed at analysis price plus data interpretation price.
Below is a table indicating the amounts of material required for the various experiments. If you do not have the recommended amounts, please contact us to discuss options.
Analytical Technique Approximate amount of sample require
XRPD 50 mg
IR 50 mg
Raman 1 mg - 100 mg
(depending on type of analysis selected)
TGA 10 mg
DSC 10 mg
Solid-state NMR 50 mg
Solution NMR-Proton 5 mg
Solution NMR-Carbon 50 mg
Moisture Sorption 20 mg
Optical Microscopy 1 mg
Hot Stage Optical Microscopy 1 mg
SEM 1 mg
EDS 1 mg