Aptuit has the capacity and capabilities to conduct pharmacokinetic evaluations in a number of species. We provide a high throughput screening service for lead candidate selection. Our studies can also support selection of dose levels, dose routes and dosing regimes.
Discovery Support Studies
Our discovery support studies provide:
- Supporting data related to selection of toxicology species
- Prediction of human PK parameters
- Assessment of any potential drug-drug interactions
- Strategic direction of future chemistry approaches by providing metabolism information
Dose administration routes
We have experience with a number of dose routes, including:
- Oral
- Intravenous (bolus and infusion)
- Subcutaneous
- Intramuscular
- Intraperitoneal
- Continuous infusion
- Intrathecal
- Intratracheal
- Portal vein access ports
Sample analysis
We administer both radiolabeled and non-radiolabeled compounds. We can provide sample analysis by LSC or LC-MS/MS and data analysis using WinNonlin.
Metabolic Profiling
We can identify the primary routes and sites of metabolism in early screening studies and thus direct future chemistry approaches towards the synthesis of more metabolically stable compounds.