Biotherapeutics engage with the immune system in many ways: from direct action on an immune target, to indirect induction of immune-mediated mechanisms. We provide tailored services to help engineer your immunological investigation to ensure a robust biotherapeutic development program.
Our expertise and services include:
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Immune Efficacy and Acute Safety – Mechanistic analyses (cytotoxicity, proliferation, mediator release), determination of species specificity (receptor pharmacology)
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Immunotoxicology – Innate and adaptive immune status (immune cell function, TDAR to KLH, lymphocyte subset distribution and activation)
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Immunoanalysis (Bioanalytical) – Immunoassay development and validation, PK/PD data from biotherapeutic and biomarker analysis
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Immunogenicity – Screening, confirmation, neutralizing activity and systemic pharmacological assessment