Lead generation is a key element of the discovery process as the quality of the leads generated during this phase has a direct impact on the speed and probability of success of the ensuing lead optimization stage.
Typically, a lead generation campaign may involve optimization of hits identified through screening activities. Our experienced scientists assess chemical tractability in combination with data from early ADMET screening and in silico developability profiling to produce a prioritized list of hits for exploration. Parallel synthesis techniques are leveraged during hit explosion to rapidly determine structure-activity relationships and define the potential of each hit series for further optimization.
Alternatively, leads series may be generated through knowledge based strategies adopting fast-follower or lead hopping approaches, exploiting our expertise in computational chemistry and experience in establishing intellectual property space.
Our fully integrated approach unites medicinal chemistry skills with computational chemistry competence, pharmacological expertise and early ADMET know-how to deliver validated leads with the desired biological activity and appropriate developability characteristics, ready for progression into lead optimization.
The following disciplines support stand alone or integrated services for Lead Generation: