Our highly skilled medicinal chemists work in close contact with colleagues from computational chemistry and other discovery disciplines to identify hits, leads and candidates of high intrinsic value. Parameters influencing the future developability of hits and leads are assessed at an early stage and addressed following specific working hypotheses. Structure-activity relationships are developed taking into account the importance of managing appropriate physicochemical characteristics to reduce the risk of compound attrition.
Aptuit's medicinal chemistry group has extensive experience across a diverse range of therapeutic areas and target classes and has a strong track record for delivering high quality leads and candidates.
We are adept at both ligand based and structure based rational drug design and have expertise in multi-stage syntheses, in working with homochiral scaffolds and in developing new synthetic routes to novel scaffolds.
Our state of the art facilities are equipped with the most advanced enabling technologies including microwave reactors, parallel synthesis devices and mass-directed autopreparative purification systems to enhance synthetic productivity.
Aptuit's medicinal chemistry group can support your discovery chemistry needs with
a series of integrated or stand-alone offerings including:
- Hit Generation
- Lead Generation
- Lead Optimization
- Chemical Series Exploration (Design and/or Synthesis)
- Hit and Lead Explosion using Parallel Synthesis
- SAR Determination
- Tool Identification
- Lead Series Identification Through Fast-Follower Approach
- Patent Exemplification